Alypius may refer to:
- Alypius of Antioch, vicarius of Roman Britain, probably in the late 350s
 - Alypius of Alexandria, music theorist, c. 360
 - Alypius of Byzantium (died 169), bishop of Byzantium
 - Alypius of Constantinople (fl. 430), Byzantine priest
 - Alypius the Stylite (died 640), ascetic saint and monastic founder
 - Alypius of Thagaste (died after 416), Catholic saint and bishop in 394
 
See also
- Alypus, ancient Greek sculptor
 
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