Apelles was a painter of ancient Greece.
Apelles may alsorefer to:
- Apelles (gnostic), the founder of a Gnostic sect in the 2nd century
 - Apelles of Heraklion, one of the Seventy Disciples
 - "Apelles", a pseudonym used by Jesuit Christoph Scheiner in writing on sunspots
 - Apelles, a synonym for the butterfly genus Glaucopsyche
 - HMS Apelles, an 1808 British Royal Navy ship
 - Matthäus Apelles von Löwenstern (1594–1648), German psalmist, musician and statesman
 
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