Chaperone or Chaperon may refer to:
- Chaperone (social) or chaperon, a person who accompanies or supervises young people on social occasions
 - Chaperone (clinical), a person who acts as a witness during a medical examination or procedure
 - Chaperon (headgear), a form of hood or hat worn in Western Europe in the Middle Ages
 
Biology
- Chaperone (protein), a protein that assists non-covalent folding/unfolding
 - Co-chaperone, a protein that assists a chaperone in protein folding and other functions
 - Pharmacological chaperone, a molecule which stabilizes protein folding, used in treatment for loss of function
 - Chaperone-mediated autophagy, a selective type of autophagy
 - MEAI or "Chaperon", a pharmaceutical drug used as a safer alternative to alcohol
 
People
- Bob Chaperon (born 1958), a retired Canadian snooker and billiards player
 - Nicolas Chaperon (died 1656), a French painter, draughtsman and engraver
 - Philippe Chaperon (1823–1907), a French scenographer
 
See also
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