Cintrón or Cintron is a surname of Puerto Rican origin. Famous people with the surname Cintron:
- Alex Cintrón (born 1978), Major League Baseball infielder
 - Carlos Juan Cintrón (1918–1998), mayor of Ponce, Puerto Rico from 1957 to 1961
 - Conchita Cintrón (1922–2009), Chilean torera (female bullfighter)
 - José Vicente Ferrer de Otero y Cintrón (1912–1992), Puerto Rican actor, theater and film director
 - Juan H. Cintrón García (1919–2012), Puerto Rican politician, Mayor of Ponce 1968–1972
 - Kermit Cintrón (born 1979), Puerto Rican boxer who is from Carolina, Puerto Rico
 - Manolo Cintron (born 1963), former Puerto Rican professional basketball player
 - Yelitza Cintron (born 1986), Singer-Songwriter from Quebradillas, Puerto Rico
 - Manuel Egozcue Cintrón (1855–1906), born in Bilbao, Spain
 - Marty Cintron, American singer, member of the American pop band No Mercy
 - Nemir Matos-Cintrón (born 1949), Puerto Rican author who currently resides in Florida
 - Nitza Margarita Cintron (born 1950), Chief of Space Medicine & Health Care Systems Office at NASA's Johnson Space Center
 - Rosendo Matienzo Cintrón (1855–1913), lawyer and political leader
 - Sharon Cintron (born 1945), American model and actress
 - Jailene Cintron (born 1966), TV Host personality and singer
 
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