FME may refer to:
Entertainment
- Film and Music Entertainment, a British film production company
 - Finnish Metal Expo, a music festival
 
Technology
- FME connector, a type of coaxial cable connector
 - FME (software), a spatial data integration and conversion application
 - Fairbanks Morse Engine, engine manufacturing subsidiary of EnPro Industries
 - Fourier–Motzkin elimination, a mathematical technique
 - Fujitsu Microelectronics Europe GmbH, former name of Fujitsu Semiconductor Europe GmbH
 
Other uses
- Federación Mexicana de Esgrima, the Mexican Fencing Federation
 - Fjármálaeftirlitið (Financial Supervisory Authority (Iceland), an Icelandic government agency
 - Force medical examiner, any doctor employed by police in the United Kingdom as an expert in a law enforcement matter
 - Forest Movement Europe, an environmental organization
 - Formal Methods Europe, an NGO for encouraging formal methods in computer hardware and software development
 - Free-market environmentalism, a political philosophy
 - FME, IATA code for Tipton Airport, in Maryland, United States
 
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