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Gascoigne (pronounced, and sometimes spelt, Gascoine or Gascoyne) is a British surname of Old French origin, the regional name of Gascony. The surname first appears on record in England in the early 13th century. Gascoigne or Gascoine may refer to:
People
- Sir Alvary Gascoigne (1893–1970), British diplomat
 - Bamber Gascoigne (1935–2022), English broadcaster and author
 - Bamber Gascoigne, fictional character in Charles Lamb's Essays of Elia (essay on Christ's Hospital)
 - Ben Gascoigne (1915–2010), New Zealand-born Australian optical astronomer and photometrist
 - Sir Bernard Gascoigne (Bernardo Guasconi, 1614–1687), Italian military adventurer and diplomat
 - Bianca Gascoigne (born 1987), English model
 - Cara Gascoigne (1888-1984), British physical educator, coach
 - Caroline Leigh Gascoigne (1813-1883), British writer
 - Charles Gascoigne (1738–1806), English industrialist, arms manufacturer and entrepreneur in Russia
 - George Gascoigne (c.1535–1577), English poet
 - Jill Gascoine (1937–2020), English actress and novelist
 - John Gascoigne (disambiguation)
 - Sir Julian Gascoigne (1903–1990), British Army general, governor of Bermuda
 - Marc Gascoigne (born 1962), English games author and editor
 - Marguerite J. Gascoigne, pseudonym of Marguerite Lazarus, née Jackson (1916–2004), British writer
 - Paul Gascoigne (born 1967), English footballer
 - Phil Gascoine (1934–2007), British comics artist
 - Rosalie Gascoigne (1917–1999), New Zealander-Australian artist
 - Richard Gascoigne (1579–1661x64), English antiquarian
 - Sheryl Gascoigne (born 1965), British television personality
 - Stephen Gascoigne ("Yabba") (1878–1942), Australian sports personality
 - Thomas Gascoigne (disambiguation)
 - William Gascoigne (disambiguation)
 
Gascoigne may also refer to:
- Oliver Gascoigne, Irish family
 - Gascoigne baronets of Yorkshire, England
 
See also
- Gascoigne Bluff, Georgia, USA
 - Gascoigne Road, Hong Kong
 - Gascoyne (disambiguation)
 - Gascoigne (film), a film about footballer Paul Gascoigne
 
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