A guess is a conjecture or estimation. To "guess" is to make a prediction without sufficient information or knowledge.
Guess, GUESS, Guessing, or Guessie may also refer to:
- Guess (clothing), an American name-brand clothing line
 - Guess (variety show), a variety show in Taiwan
 - Guess (JoJo's Bizarre Adventure), a character in the Japanese manga JoJo's Bizarre Adventure
 
People
- Alvaleta Guess (1955–1996), American stage/musical theatre actress
 - Carol Guess (born 1968), American novelist and poet
 - Elizabeth Guess (born 1985), American soccer forward and midfielder
 - Francis Guess (1946–2015), American businessman and civil rights advocate
 - Gene Guess (1932–1975), American lawyer and politician
 - George Guess (disambiguation)
- Sequoyah (c. 1770–1843), Cherokee silversmith, named in English George Gist or George Guess
 - George W. Guess (1822–1868), mayor of Dallas, Texas, 1866–1868
 
 - Gretchen Guess (born 1969), American businesswoman and politician
 - Jeff Guess (born 1948), Australian poet
 - Sam C. Guess (1909–1989), American politician from the State of Washington
 
See also
- GESS (disambiguation)
 - Güssing, a town in Burgenland in Austria
 - Güssing District, an area in Burgenland in Austria
 - Guessing Game (disambiguation)
 - Guesswork (album), a 2019 album by Lloyd Cole
 
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