ISG may refer to:
Academics
- Information Security Group, academic information security group in Royal Holloway, University of London
 - Indian School, Al-Ghubra, a K-12 school in Muscat, Oman
 - International School of Geneva, an international school in Geneva, Switzerland
 - International School in Genoa, an international school in Genoa, Italy
 - International School Groningen, an international school in Haren, Netherlands
 - ISG Business School, a business school in Paris, France
 
Organisations
- Idaho State Guard, active during World War II
 - Independent Senators Group, a Canadian Senate parliamentary group
 - Interactive Support Group, a defunct CD-I development company
 - International Steel Group, a steel company headquartered in Cleveland, Ohio
 - Interserve Group, a UK construction company
 - Iowa State Guard, active during World War II
 - ISG Ltd, a UK construction company
 
Transportation
- Integrated Starter-Generator, part of an automotive start-stop system
 - New Ishigaki Airport (IATA airport code) on Ishigaki Island, Okinawa, Japan
 
Other uses
- In situ gasification, a process in underground coal gasification (UCG)
 - Instruction Stream Generator, also called random test generator
 - Interferon-stimulated genes, a varied group of genes that are switched on by interferon to tackle viral infection
 - International Socialist Group, a Trotskyist group and British section of the Fourth International between 1987 and 2009
 - Iraq Study Group, a 2006 congressionally appointed panel charged with assessing the situation in Iraq, also known as the Baker-Hamilton Commission
 - Iraq Survey Group, the 2003–2005 investigative mission in the Iraqi WMD search program that produced the Duelfer Report
 - Irish Sign Language (ISO 639 code 
isg) 
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