Route 105 or Highway 105 may refer to:

Argentina

• National Route 105
• La Pampa Provincial Route 105

Canada

• New Brunswick Route 105
• Nova Scotia Highway 105 (Trans-Canada Highway)
• Ontario Highway 105
• Prince Edward Island Route 105
• Quebec Route 105

China

• China National Highway 105
• S105 Nansha Port Expressway (Guangdong)

Costa Rica

• National Route 105

India

• National Highway 105 (India)

Japan

• Route 105 (Japan)

Philippines

• N105 highway (Philippines)

South Korea

• Namhae Expressway Branch 3

United States

• Interstate 105
• Alabama State Route 105
• Arkansas Highway 105
• Colorado State Highway 105
• Florida State Road 105
• Georgia State Route 105
  • Georgia State Route 105 (1932–1937) (former)
• Illinois Route 105
• Indiana State Road 105
• Iowa Highway 105 (former)
  • County Road 105 (Mitchell County, Iowa)
  • County Road 105 (Worth County, Iowa)
• K-105 (Kansas highway)
• Kentucky Route 105
• Louisiana Highway 105
  • Louisiana State Route 105 (former)
• Maine State Route 105
• Maryland Route 105 (former)
• Massachusetts Route 105
• M-105 (Michigan highway) (former)
• Minnesota State Highway 105
• Missouri Route 105
• Nebraska Highway 105
• County Route 105 (Bergen County, New Jersey)
  • County Route 105 (Ocean County, New Jersey)
• New Mexico State Road 105
• New York State Route 105
  • County Route 105 (Dutchess County, New York)
  • County Route 105 (Erie County, New York)
  • County Route 105 (Montgomery County, New York)
  • County Route 105 (Nassau County, New York)
  • County Route 105 (Niagara County, New York)
  • County Route 105 (Onondaga County, New York)
  • County Route 105 (Orange County, New York)
  • County Route 105 (Seneca County, New York)
  • County Route 105 (Steuben County, New York)
  • County Route 105 (Suffolk County, New York)
  • County Route 105 (Sullivan County, New York)
    • County Route 105A (Sullivan County, New York)
  • County Route 105 (Tompkins County, New York)
• North Carolina Highway 105
• Ohio State Route 105
• Oklahoma State Highway 105
• Pennsylvania Route 105 (former)
• South Carolina Highway 105
• South Dakota Highway 105 (former)
• Tennessee State Route 105
• Texas State Highway 105
  • Texas State Highway Loop 105
  • Texas State Highway Spur 105 (former)
  • Farm to Market Road 105
• Utah State Route 105
• Vermont Route 105
  • Vermont Route 105A
• Virginia State Route 105
• Washington State Route 105
• West Virginia Route 105
• Wisconsin Highway 105

Territories

• Puerto Rico Highway 105

See also

• A105
• B105 road
• D105 road
• P105
• R105 road (Ireland)