PBC may refer to:
Organisations
General terms
- Public-benefit corporation (disambiguation)
 - Prescribed Body Corporate, or Registered Native Title Body Corporate, a type of legal entity in Australia
 
Broadcasting
Sports
- Premier Boxing Champions, televised boxing event
 - Peach Belt Conference, US sports conference
 
Other
- Pakistan Bar Council
 - Pakistan Business Council
 - Parole Board of Canada
 - Party of Bible-abiding Christians (Partei Bibeltreuer Christen), Germany
 - Peacebuilding Commission, United Nations body
 - People's Bank of China
 - Pittsburgh Brewing Company
 
Places
- Hermanos Serdán International Airport, Puebla, Mexico by IATA airport code
 - Palm Beach County, Florida.
 
Schools
- Palm Beach Currumbin State High School, Queensland, Australia
 - Portland Bible College, Oregon, United States
 - Presentation Brothers College, Cork
 
Science and technology
- Periodic boundary conditions
 - Primary biliary cholangitis or primary biliary cirrhosis
 - .pbc, filetype of Parrot bytecode in Parrot virtual machine
 - Push Button Connect
 - Playback Control, a feature on Video CD and Super Video CD
 
Other uses
- Peru-Bolivian Confederation a short-lived post-spanish federal state
 - Performance-based contracting
 - Practice-based commissioning
 - Process-based costing
 - President Bill Clinton
 
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