SIRT can refer to :
- Selective internal radiation therapy for cancer
 - Serious Incident Response Team, Nova Scotia, Canada
 - Sirtuin, a class of proteins (enzymes) related to genetics
 - Staten Island Railway (from abbreviation Staten Island Rapid Transit)
 
See also
- Siirt, a city in Turkey
 - Sirt, another name for Sirte, a city in Libya
 - Sirte (disambiguation)
 
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