Santarelli is an Italian surname. Notable people with the surname include:
- Andrea Santarelli (born 1993), fencer
 - Antonio Santarelli (archaeologist) (1832–1920), Italian archaeologist
 - Antonio Santarelli (Jesuit) (1569–1649), Italian Jesuit
 - Daniele Santarelli (born 1981), volleyball coach
 - Emilio Santarelli, 19th-century Tuscan sculptor
 - Giuseppe Santarelli (1710–1790), composer and singer
 - Simone Santarelli, footballer
 
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