Scheele is a surname of Germanic origin. Notable people with the surname include:
- Carl Wilhelm Scheele (1742–1786), German-Swedish pharmaceutical chemist
 - George Heinrich Adolf Scheele (1808–1864), German botanist
 - Karin Scheele (b. 1968), Austrian politician; member of the European Parliament since 1999
 - Leonard A. Scheele (1907–1993), American physician; Surgeon General of the United States, 1948-56
 - Nick Scheele (1944–2014), British businessman; chief operating officer of Ford Motor Company
 - Thomas von Scheele (b. 1969), Swedish table tennis player
 
See also
- Scheele (crater), the lunar impact crater
 
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