Shain may refer to:
Places
- Shain, alternate name of Hashatjin, a city in Ardabil Province, Iran
 
People
- Charles Alexander Shain (1922–1960), Australian astronomer
 - Eva Shain (1918–1999), American boxing judge
 - Irving Shain (1926–2018), American academic
 - Jon Shain (born 1967), American folk musician
 - Merle Shain (1935–1989), Canadian author and journalist
 - Milton Shain, (born 1949), South African historian
 - Ruchoma Shain (1914–2013), American teacher and author
 - Yossi Shain (born 1956), Israeli academic and politician
 
See also
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