Sisson is a surname that appeared in rural England around West Riding, Yorkshire in the 15th century. Notable people with the surname include:
- C. H. Sisson (1914–2003), British writer
 - Fred Sisson (1879–1949), United States Representative from New York
 - Jeremiah Sisson (1720–1783), British instrument maker
 - John Richard Sisson (born 1936), acting president of the Ohio State University
 - Jonathan Sisson (1690–1749), British instrument maker
 - Marshall Sisson (1897–1978), British architect
 - Rosemary Anne Sisson (1923–2017), British writer and screenwriter
 - Rufus Sisson (1890–1977), American college basketball player
 
See also
- Sisson Documents, forged Russian documents which purported that Trotsky and Lenin were agents in the pay of the German government
 - Sisson, California, now Mount Shasta, California, named after prominent land owner Justin Sisson
 - Sissons (disambiguation)
 
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