Southern Freeway may refer to:
- Southern Freeway, a freeway in New South Wales, Australia, now known as Princes Motorway
 - Interstate 280 (California), original name Southern Freeway
 - Tabriz Southern Freeway, Turkey
 - Second Southern Highway that crosses Ligang Bridge, Taiwan
 - Southern freeway near Ilz, Styria, Austria
 - Southern Freeway, early name for the B921 Kinglassie Road, Glenrothes, Scotland
 
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