System One, System I or System 1 may refer to:
Computing
- Acorn System 1, 8-bit microcomputer by Acorn
 - Atari System 1, an arcade game hardware platform by Atari
 - Cromemco System One, a microcomputer from the early 1980s by Cromemco
 - IBM Q System One, a 2019 circuit-based commercial quantum computer by IBM
 - Line Drawing System-1, an early graphical computer
 - Sega System 1, the arcade system board
 - System 1, the initial operating system version for the Apple Macintosh
 - Tulip System-1, 16-bit personal computer by Tulip
 
Other uses
- System-1 Aira, a synthesizer produced by Roland
 - System One, a range of bus passes offered by Transport for Greater Manchester
 - System 1, the fast, automatic mode of thinking, as described in Daniel Kahneman's book Thinking, Fast and Slow
 
See also
- System I (disambiguation)
 - SystmOne, a clinical and administrative software system developed by TPP (The Phoenix Partnership) company.
 - Series 1
 - System One, a workforce solutions process
 
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