Twiggs may refer to:
In ships:
- USS Twiggs (DD-127), a US Navy destroyer during World War I
 - USS Twiggs (DD-591), a US Navy destroyer during World War II
 
- Geography
 
People with the surname Twiggs:
- David E. Twiggs (1790–1862), US soldier during the War of 1812 and Mexican War, and a general in the Confederate States Army during the American Civil War
 - John Twiggs (1750–1816), leader in the Georgia Militia during the American Revolutionary War
 - Levi Twiggs (1793–1847), officer in the US Marine Corps during the War of 1812, the Seminole Wars and the Mexican–American War
 - Sarah Lowe Twiggs (1839-1920), American poet
 
See also
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