Wynne is a surname of Welsh origin. This is a list of notable people with the surname, sorted by profession:
Art, literature, and music
- Bill Wynne (1922–2021), American photographer and writer
 - David Wynne (composer) (1900–1983), Welsh composer
 - David Wynne (sculptor) (1926–2014), British sculptor
 - Frank Wynne (born 1962), Irish translator and writer
 - Ed Wynne (born 1961), British musician and son of sculptor David Wynne
 - Ed Wynne (saxophonist), musician with the Doobie Brothers
 - Gladys Wynne, Irish watercolour artist
 - Giustiniana Wynne (1737–1791), Anglo-Venetian author, aka Countess Orsini-Rosenberg of Austria
 - Madeline Yale Wynne (1847−1918), American artist, teacher, and philanthropist
 - Michael Wynne (playwright), British playwright
 - Philippé Wynne (1941–1984), American R&B vocalist
 - Richard Wynne (c.1821–1895), Australian arts benefactor, established Wynne Prize
 
Athletes
- Ian Wynne (born 1973), British flatwater canoeist
 - John Wynne (ice hockey) (born 1971), Canadian ice hockey defenceman
 - Marvell Wynne (baseball player) (born 1959), American baseball outfielder
 - Marvell Wynne (soccer) (born 1986), American football player
 - Susan Wynne (fl. 1987–94), American figure skater
 
Law, military, and politics
- Sir Arthur Singleton Wynne (1846–1936), British army general from Ireland
 - Edward Wynne (chancellor) (1681–1755), Welsh lawyer and landowner
 - Edward Wynne (colonial governor) (fl. 1621–26), early Newfoundland colonist, proprietary governor of the Ferryland colony from 1621 to 1626
 - Edward Wynne (jurist) (1734–1784), English lawyer and scholar
 - Edward Wynne-Pendarves (1775–1853), British politician
 - Greville Wynne (1919–90), British spy
 - Kathleen Wynne (born 1953), Canadian politician - Premier of Ontario
 - Khalid Shameem Wynne (1953–2017), Pakistani four-star general and Chairman of the Joint Chiefs of Staff Committee
 - Michael Wynne (born 1944), American businessman, Secretary of the Air Force
 - Robert Wynne (1851–1922), American politician
 - Robert Wynne (Virginia politician) (1622–75), Virginia colonial politician, Speaker of the Virginia House of Burgesses
 - William Watkin Edward Wynne (1801–1880), Welsh politician and antiquarian
 
Other
- Angus G. Wynne (1914–1979), American businessman, founder of Six Flags theme parks
 - Arthur Wynne (1862–1945), English-American inventor of the crossword puzzle
 - Arthur Beavor Wynne (1837–1906), Irish geologist
 - Billy Wynne (1919-2000), Church of Ireland cleric & founder of the Samaritans in Ireland
 - Ellis Wynne (1671–1734), Welsh clergyman
 - Emanuel Wynne (fl. c. 1700), French pirate
 - Henry John Wynne (1864–1950), New Zealand engineer
 - Jane Wynne (1944–2009), English paediatrician
 - Jay Wynne (fl. since 1994), British television & radio weather forecaster
 - Lyman Wynne (1925–2007), American psychiatrist and psychologist
 - Owen Wynne (disambiguation), several people of this name
 - George Robert Wynne (1833-1912), Church of Ireland cleric and author
 
See also
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